Research Peptide

TB-500 — Thymosin Beta-4 Fragment

Tissue Repair & Recovery. TB-500 is a synthetic fragment of Thymosin Beta-4, a naturally occurring peptide present in virtually all human and anim...

Sequence
43 Amino Acids
Category
Research Peptide
Primary Use
Tissue Repair
Administration
SubQ

What Is TB-500?

TB-500 is a synthetic fragment of Thymosin Beta-4, a naturally occurring peptide present in virtually all human and animal cells. It has been extensively studied for its role in wound healing, tissue repair, and the regulation of actin — a cell-building protein critical to tissue regeneration and cell migration.

tissue repair recovery wound healing actin

Mechanism of Action

TB-500 promotes healing through its interaction with actin, enabling cell migration to injury sites. It upregulates cell-building proteins and promotes angiogenesis — formation of new blood vessels that accelerate nutrient delivery to damaged tissues. Research also indicates anti-inflammatory properties through downregulation of inflammatory cytokines. Its small molecular size allows high systemic bioavailability.

Key Research Findings

  • Wound healing — Animal studies demonstrate significantly accelerated wound closure in skin, corneal, and cardiac tissue
  • Muscle repair — Rodent models show improved recovery from muscle strain with faster return to baseline function
  • Tendon/ligament healing — Studies report improved tensile strength and collagen organization in healing tendons
  • Cardiac repair — Murine models show reduced scar tissue and improved cardiac function post-myocardial infarction
  • Hair regrowth — Limited preclinical data suggests effects on hair follicle stem cell migration

Important: The evidence base for TB-500 varies by application. Many findings are from preclinical (animal or in vitro) studies. Large-scale human clinical trials may not be completed. Always evaluate the quality of evidence before drawing conclusions.

Known Side Effects

TB-500 has shown a favorable safety profile in preclinical research. Commonly reported anecdotal effects include mild headache, temporary lethargy, and injection site irritation. Long-term human safety data has not been established through clinical trials.

Legal Status (2026)

Where to Buy TB-500 for Research

These verified suppliers carry TB-500 with third-party COAs and US-based shipping.

BP
BioPure Peptides
USA-made · 99%+ purity · WHO/GMP certified
  • Third-party tested with COAs on every batch
  • Ships from Chandler, AZ — free shipping over $200
  • 30+ peptides in catalog including blends and stacks
Shop BioPure Peptides →
AC
Amino Club
US-based · 99%+ purity · COAs on every batch
  • Same-day shipping on orders before 2 PM EST
  • HPLC + Mass Spec tested by US-accredited labs
Use code POWER for 20% off your first order
Shop Amino Club →
AP
Apollo Peptide Sciences
Oxnard, CA · Research-grade · Third-party verified
  • Ships within 48 hours via USPS Priority/Express
  • Full COAs available on every product
  • Free shipping on orders over $200
Shop Apollo Sciences →
MW
Midwest Peptide
Mission, KS · Same-day shipping · COAs on every page
  • Same-day UPS shipping from US facility
  • Free shipping on every order
  • 5% additional discount with Zelle payment
Use code POWER for 10% off
Shop Midwest Peptide →
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